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Accueil du site > Research teams > Molecular Evolution & Phylogeny > People > Researchers & Teachers > Nicolas GALTIER > Nicolas GALTIER
Nicolas GALTIER
Research area : Molecular evolution, molecular phylogeny, population and evolutionary genomics, bioinformatics.
Associate Editor : Journal of Molecular Evolution, Biology Direct, Faculty of 1000
Big questions I would like to answer (eventually) :
Why are fast-evolving genomes fast ?
Does population size matter ?
Why is mitochondrial DNA hypermutable in (most) animals but not in plants ?
How much does GC-biased gene conversion impact functional genome evolution (in human) ?
Should you build trees in case of horizontal gene transfer, and how ?
Selected publications 2003-2008 (by topic) :
Mitochondrial genome evolution
Nabholz B., Glémin S. & Galtier N. 2008. Strong variations of mitochondrial mutation rate across mammals – the longevity hypothesis. Molecular Biology and Evolution 25 : 120-130.
Nabholz B., Mauffrey J.F., Bazin E., Galtier N. & Glémin S. 2008. Determination of mitochondrial genetic diversity in mammals. Genetics 178 : 352-361.
Bazin E., Glémin S. & Galtier N. 2006. Population size does not influence mitochondrial genetic diversity in animals. Science 312 : 570-571.
Galtier N., Enard D., Radondy Y., Bazin E. & Belkhir K. 2006. Mutation hot spots in mammalian mtDNA. Genome Research 16 : 215-222.
GC-content evolution, biased gene conversion
Galtier N. & Duret L. 2007. Adaptation or biased gene conversion ? Extending the null hypothesis of molecular evolution. Trends in Genetics 23 : 273-277.
Duret L., Eyre-Walker A. & Galtier N. 2006. A new perspective on isochore evolution. Gene 385 : 71-74.
Galtier N., Bazin E. & Bierne N. 2006. GC-biased segregation of non-coding polymorphisms in Drosophila. Genetics 172 : 221-228.
Galtier N. 2004. Recombination, GC-content, and the human pseudoautosomal boundary paradox. Trends in Genetics 20 : 347-349.
Marais G. & Galtier N. 2003. Sex chromosomes : how X-Y recombination stops. Current Biology 13 : 641-643.
Galtier N. 2003. Gene conversion drives GC-content evolution in mammalian histones. Trends in Genetics 19 : 65-68.
Montoya-Burgos J.I., Boursot P. & Galtier N. 2003. Recombination explains isochores in mammalian genomes. Trends in Genetics 19 : 128-130.
Markov models, phylogeny
Penn O., Stern A., Rubinstein N., Dutheil J., Bacharach E., Galtier N. & Pupko T. 2008. Specificity determinants in HIV-1 subtypes as revealed by an evolutionary model of rate shifts. PLoS Computational Biology (in press)
Galtier N. & Daubin V. 2008. Dealing with incongruence in phylogenomic analyses. Philosophical Transactions of the Royal Society B (in press)
Dutheil J. & Galtier N. 2007. Detecting groups of coevolving positions in a molecule : a clustering approach. BMC Evolutionary Biology 7 : 242.
Galtier N. 2007. A model of horizontal gene transfer and the bacterial phylogeny problem. Systematic Biology 56 : 633-642.
Galtier N., Gascuel O. & Jean-Marie A. 2005. An introduction to Markov models in molecular evolution. Pp 3-24 in "Statistical Methods in Molecular Evolution", R. Nielsen, Ed., Springer.
Dutheil J., Pupko T., Jean-Marie A. & Galtier N. 2005. A model-based approach for detecting coevolving positions in a molecule. Molecular Biology and Evolution 22 : 1919-1928.
Galtier N. 2004. Sampling properties of the bootstrap support in molecular phylogeny : influence of non-independence between sites. Systematic Biology 53 : 38-46.
(Pure) bioinformatics
Dutheil J., Gaillard S., Bazin E., Glémin S., Ranwez V., Galtier N. & Belkhir K. 2006. Bio++, a set of C++ libraries for sequence analysis, phylogenetics, population genetics and molecular evolution. BMC Bioinformatics 7:188.
Bazin E., Duret L., Penel S. & Galtier N. 2005. Polymorphix : a sequence polymorphism data base. Nucleic Acids Research 33 : 481-484.
Miscellaneous
Gayral P., Caminade P., Boursot P. & Galtier N. 2007. The evolutionary fate of recently duplicated retrogenes in mice. Journal of Evolutionary Biology 20 : 617-626.
Alvarez N., Benrey B., Hossaert-McKey M., Grill A., McKey D. & Galtier N. 2006. Phylogeographic support for horizontal gene transfer involving sympatric bruchid species. Biology Direct 1:21.
Guldner E., Godelle B. & Galtier N. 2004. Molecular adaptation in plant hemoglobin, a duplicated gene involved in plant-bacteria symbiosis. Journal of Molecular Evolution 59 : 416-425.
Guldner E., Desmarais E., Galtier N. & Godelle B. 2004. Molecular evolution of plant hemoglobin : two hemoglobin genes in Nymphaeaceae Euryale ferox. Journal of Evolutionary Biology 17 : 48-54.
par Douzery Emmanuel - Mis à jour/Updated : 10 mars 2009
